When the amount of negative ions in the blood increases, there is an increase in inter-cellular communication. Cellular metabolism is facilitated and as a result there is an increase in cellular nutrient uptake and cellular hydration. In addition, cellular waste materials are more efficiently excreted. With the increase in cellular metabolism, optimal cell function is rapidly revived. Further information on the positive influence of negative ions can be found in research conducted by scientists awarded the Nobel Prize in Physiology (1991) for the discovery of ionic channel function.